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| Bioinformatics and Proteomics https://jacobspublishers.com/jacobs-journal-of-bioinformatics-and-proteomics/#1529649745424-bab73f96-358d Our approach has been to enhance ligand binding by linkingseparate ligands into a single combined ligand that wouldcombine the affinities of the separate ligands. For the individual ligands, we used oligopeptides designed to bind EphA4 byObarska-Kosinska and Tramontano We describe the method we developed for selecting pairs of peptides from theset they provided, and for designing linkers to create a dimeric ligand while maintaining the structures and interactions of the original individual oligopeptides. We have coordinated the use of several publicly-available web servers that do the heavylifting. |
